The effect of endurance training on addicted women’s level of alkaline phosphates who use methadone

Document Type : Original Article

Authors

• Farah Haddadi ¹
• Mojgan Jazizadeh-Karimi ²
• Mazhar Rostami Nejad ³
• Saied Sokhtehzari ²
• Amir Hossein Monazami ⁴
• Mohammad Reza Asad ⁵

¹ Faculty of Human Science, Tehran Payamenoor University, Tehran, Iran

² Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

³ Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

⁴ Faculty of Sport, Tehran University, Tehran, Iran

⁵ Research Section of Payamenoor University, Tehran, Iran

Abstract

Introduction: Previous studies indicated that endurance exercise is effective to decrease or increase the levels of liver enzymes. The aim of this study was to determine the effect of endurance training on alkaline phosphates (ALP) enzyme in Iranian addicted women with methadone.
Methods: Thirty Iranian female addicted prisoners and thirty non-addicted encompassed the sampling. The mean of age, height, weight, %BF, body mass index (BMI), and VO2max of experimental group was 33.8 years, 162.2 cm, 62.2 kg, 33.10, 24.22 kg/m2 and 16.18 ml/kg respectively. The case group was supposed to run with 65% HRmax for 2 weeks (3 sessions in a week and for 25 minutes), 65%-75% HRmax for 3 weeks (3 sessions in a week for 35 minutes) and 75%-85% HRmax for 3 weeks (3 sessions in a week for 40 minutes). The blood samples were collected in amount of 5 ml 48 hours before the first session and after the last session of the protocol. The history of heart and liver diseases or hepatitis was not reported in case group.
Results: The level of ALP between case and control group in post-test was not significant. The level of ALP in post-test in contrast with pre-test in both groups was increased but this was not statistically significant in case group (P > 0.05).
Conclusion: According to the results, the level of ALP in post-test in experimental group did not change after endurance training. Therefore, the investigation of other factors such as having suitable diet habits, quitting smoking, increasing the period of training is recommended for these types of addicts.

Keywords

• Alkaline phosphates
• Liver
• Methadone
• Endurance Training

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References

1. Naderi S, Binazadeh M, Noruzi MR, Safaeeyan S. Complete guidance for curing of addiction. 2nd ed. 2005. [In Persian].

2. Robergs RA, Riberts S. Fundamental principle of exercise physiology. 2nd ed. USA: McGraw Hill; 2000.

3. Henry JB. Davidson’s Clinical Biochemistry. Translators: Pakzad S, Ezhdari S, Eghtesad M. Tehran: Daneshpazhuh population; 1993.

4. Karanth J, Kumar R, Jeevaratnam K. Response of antioxidant system in rats do dietary fat and physical activity. Indian J Physiol Pharmacol 2004; 48(4): 446-52.

5. Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. Diagnosis and monitoring of hepatic injury. Performance characteristics of laboratory tests. Clin Chem 2000; 46(12): 2027-49.

6. Tafrashi H. The statistic of addict people in Iran. Iran Razi Institute; 2011; 23(2): 144-51. [In Persian].

7. Asad MR, Haddadi F, Rostami Nejad M, Sokhtehzari S. Effect of eight weeks endurance exercise on liver enzymes in stopping drug women with methadone. Journal of Paramedical Sciences 2013; 4 (Supplement): 68-71.

8. Noakes TD, Carter JW. The responses of plasma biochemical parameters to a 56-km race in vovice and experienced ultra-marathon runners. Eur J Appl Physiol Occup Physiol 1982; 49(2): 179-86.

9. Wu HJ, Chen KT, Shee BW, Chang HC, Huang YJ, Yang RS. Effect of 24 h ultra-marathon on biochemical and hematological parameters. World J Gastroenterol 2004; 10(18): 2711-4.

10. Córdova A, Martin JF, Reyes E, Alvarez-Mon M. Protection against muscle damage in competitive sport player: The effect of the immunomodulater AM3. J Sports Sci 2004; 22(9): 827-33.