Effect of 12 Weeks Aerobic Training with Ginger Consumption on IL-18 and CRP in Obese Men

Document Type : Original Article

Authors

• Mohammad Sorani ¹
• khosro jalali ²
• Ali Jalali Dehkordi ³

¹ Department of Sport Physiology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

² Depatrtment of Sport Physiology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

³ Department of Sport Physiology, Urmia University, Urmia, Iran

Abstract

Introduction: The use of antioxidant and anti-inflammatory supplements is important in improving the function of obese people. The aim of this study was to investigate the effect of 12 weeks aerobic training with ginger consumption on the levels of IL-18 and CRP in obese men. Methods: 40 men (mean ± SD: age 23.9 ± 5.90 years old, weight 87.61 ± 4.69 kg and BMI 32.69 ± 3.25 kg / m2) were randomly selected and divided into four groups of 10, including 1- aerobic training, 2- training with ginger consumption, 3-ginger consumption, 4-control. The first and second groups, had 12 weeks, 3 sessions per week and 40 minutes each session aerobic training selections with an intensity of 65%MHR; during this period, the second and third groups received one gram of ginger capsule daily and the control group received no intervention. Blood samples were taken before and after the study period. Paired sample t-test and one-way ANOVA were used for data analysis (p≤0.05).
Results: There was a significant difference in IL-18 and CRP before and after exercise in all three experimental groups (p≤0.05).. Also, the results of the bonferroni post hoc test showed a significant difference in the level of IL-18 and CRP in the Reaserch groups. The highest decrease in these variables was observed in the aerobic training group and training with ginger consumption group (p≤0.05). Conclusion: Ginger supplementation with aerobic training seems to be a suitable method for reducing IL-18 and CRP and preventing metabolic, cardiovascular and inflammatory diseases in obese men.

Keywords

• Aerobic Training
• Ginger
• IL-18
• CRP
• Obesity

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References

1. Janghorbani M, Amini M, Willett W, Mehdi Gouya M,Delavari A, et al, First Nationwide Survey of Prevalence of Overweight, and Abdominal Obesity in Iranian Adults .Obesity. 2007; 15 (11): 2797- 2808.

2. Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged older us adults. Arch Intern Med. 2002; 162: 1286- 1292.

3. Skurk T, Kolb H, Muller-Scholze S, Rohrig K, Hauner H, Herder C. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol. 2005; 152: 863- 868.

4. Leick L, Lindegaard B, Stensvold D, Plomgaard P, Saltin B, Pilegaard H. Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise. Obesity. 2007; 15: 356- 363.

5. Haghjoo M, Abdossaleh Z, Hoseini SA. Effect of 8-week Zumba training on overweight woman’s body composition. PJMS. 2016; 14 (2): 21- 30.

6. Esposito K, Nappo F, Giugliano F, Di Palo C, Ciotola M, Barbieri M, et al. Cytokine milieu tends toward inflammation in type 2 diabetes. Diabetes Care. 2003; 26 (5): 2067- 2072.

7. Zirlik A, Abdullah SM, Gerdes N, MacFarlane L, Schonbeck U, Khera A, et al. Interleukin- the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas heart study. Arterioscler Thromb Vasc Biol. 2007; 27 (9): 2043- 2049.

8. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines

activity in coronary heart disease patients. Int J Cardiol. 2005; 100 (1): 93- 99.

9. Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation. 2002; 105 (5): 564- 569.

10. Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, KolahdoozF.

The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials Critical. Food Sci Nutr. 2018; 2 (1): 1- 15.

11. Atashak S, Piri M, Afari A, Azarbayejani M. Effect of resistance training and ginger intake on CRP and Cardiovascular risk factors in Obese men. Phys Pharm. 2010; 3: 323- 313.

12. Khosravianfar M, Jalali Dehkordi K, Sharifi G, Jalali Dehkordi A.Comparison of the effect of period of resistance, aerobic and concurrent training on irisin, CRP serum levels in obese women. .J Shahrekord Univ Med Sci. 2018; 20 (2): 13- 23.

13. Zhang YF, Yang YS, Hong J, Gu WQ, Shen CF, Xu MDu PF, et al. Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome. Endocrin. 2006; 29: 419- 423.

14. Gokhale R, Chandrashekara S, Vasanthakumar KC. Cytokine response to strenuous exercise in athletes andnon-athletes-an adaptive response. Cytokine. 2007; 40: 123- 127.

15. Esposito K, Pontillo A, Ciotola M, Di Palo C, Grella E, Nicoletti G. Giugliano D. Weight loss reducesinterleukin-18 levels in obese women. J Clin Endocrinol Metab. 2002; 87: 3864- 3866.

16. Nayebifar S, Afzalpour MS, Kazemi T, Abtahi Eivary SH, Mogharnasi M. The effect of a 10‑week high‑intensity interval training and ginger consumption on inflammatory indices contributing to atherosclerosis in overweight women. JRMS. 2016; 7 (21): 1- 7.

17. Vahdatpoor H, Alizadeh AA, Shakerian S. The effect of ginger supplement on oxidative stress induced by overweight extrinsic exertion and overweight. JBUMS. 2018; 24 (4): 282- 290.

18. Troseid M, Lappegard KT, Mollnes TE, Arnest H, Seljeflot I. The effect of exercise on serum level of interleukin-18 and components of the metabolic syndrome. Metab Syndr Relat Disord. 2009;7: 579- 584.

19. Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 2013; 1- 9.

20. Christopher JK, Hammett M, Prapavesis H, Baldi C, Varo N, Schoenbeck U, et al.

Effects of exercise training on inflammatory markers associated with cardiovascular risk. Am Heart. 2006; 151 (2): 367- 389.

21. Ford E. Does exercise reduce inflammation? Physicalactivity and C-reactive protein among U. S. adults. Epidemiology. 2002; 13: 561- 568.

22. Kohurt ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, et al. Aerobic exercise, but not

flexibility/resistance exercise, reduces serum IL-18, CRP,and IL-6 independent of Beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun.2006; 20: 201- 209.

23. Wong PC, Chia MY, Tsou IY, WansaicheongGK, Tan B, Wang JC, et al. Effects of a 12-weekexercise training program on aerobic fitness, body composition, blood lipids and C-reactive protein in adolescents with obesity. Ann Acad Med Singapore. 2008; 37 (4): 286- 293.

24. Lindegaard B, Hansen T, Hvid G, van Hall G, Plomgaard P, Ditlevsen S, et al. The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy. J Clin

Endocrinol Metab. 2008; 93 (10): 3860- 3869.

25. Thomson M, Al-Qattan KK, Al-sawan SM, Alnaqeeb MA, IKhan AM. The use of ginger (zingiber officinale Rosc) as a potential anti-inflammatory and antithrombotic agent. PLEFA. 2002; 67: 475- 478.

26. Shanmugam KR, Mallikarjuna K, Kesireddy N, Reddy KS. Neuroprotective effect of ginger onanti-oxidant enzymes in streptozotocin-induced diabetic rats. FCT. 2011; 49 (4): 893- 897.

27. Mazidi M, Gao H K, Rezaie P, Ferns GA. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis. FNR. 2016; 60: 1- 9.

28. Wang S, Zhang C, Yang G, Yang Y. Biological properties of 6-gingerol: a brief review. NPC. 2014; 9 (7): 1027- 1030.

29. Arabloo A, Valizadeh M, Hoseyni A, Jalali M. Effect of ginger supplementation on cardiovascular risk in diabetic patient. RJMS. 2009; 21 (2): 1- 10.

30. Amani SS, Agha Alinejad H, Gharakhanlou R, Molanouri Shamsi M, Talebi Badrabadi K. The effect of body composition and physical activity on basal level of insulin,glucose,IL-18,IL-6&CRP and their relationship wite insulin resistance .Iran J Endicrinol Metab. 2009; 11 (6): 699- 706.