The Effects of Endurance and Resistance Training on Systemic Inflammatory Markers and Metabolic Syndrome Parameters in Overweight and Obese Men

Document Type : Original Article

Authors

• Khalid Mohamadzadeh Salamat ¹
• Nuredin Bakhtiari ²

¹ Department of Physical Education and Sport Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

² Department of Biochemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

Abstract

Introduction: The purpose of this study was to investigate the effects of endurance and resistance training on systemic inflammatory markers and metabolic syndrome parameters in overweight and obese men. Methods: 33 volunteer participants (BMI=27.39 kg/m2) were randomly divided into three groups (n=11), namely, an endurance training (ET) group, a resistance training (RT) group, and a control group. The ET and RT groups trained for eight weeks at three sessions a week and 150 min per week. Before the training and 72 hours after the last exercise session, blood samples were collected from the subjects for assays on interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), adiponectin, intracellular adhesion molecule-1 (ICAM-1), high-sensitivity C-reactive protein (hs-CRP), glucose, insulin, and blood lipids and lipoproteins. The percentage body fat, waist circumference, WHR, and blood pressure of the subjects were also measured before and after the training protocols. Analysis of variance (ANOVA) with repeated measures test and significant level of 0.05 was used for all statistical analysis. Results: After training, the ET and RT groups showed a significant decrease in hs-CRP, percentage body fat, insulin and insulin resistance index, triglycerides, and total cholesterol (P<0.05). Both groups likewise showed a significant increase in adiponectin (P<0.05). Only the changes in LDL-C and TNF-α were significant between the ET and RT groups (P<0.05). Conclusion: In general, the effects of resistance training on some of the systemic inflammatory markers and metabolic syndrome parameters of the overweight and obese men were incomparable to those of endurance training.

Keywords

• Training
• Systemic Inflammation
• Metabolic Syndrome
• Obesity

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References

1. Yatsuya H, Li Y, Hilawe EH, Ota A, Wang C, Chiang C, and et al. Global trend in overweight and obesity and its association with cardiovascular disease incidence. Circ J. 2014; 78 (12): 2807- 2818.

2. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure‐time physical activity and reduced plasma levels of obesity‐related inflammatory markers. Obesity. 2003; 11 (9): 1055- 1064.

3. Mathieu P, Pibarot P, Larose É, Poirier P, Marette A, Després JP. Visceral obesity and the heart. Int J Biochem Cell Biol. 2008; 40 (5): 821- 836.

4. You T, Arsenis NC, Disanzo BL, LaMonte MJ. Effects of exercise training on chronic inflammation in obesity. Sports Med. 2013; 43 (4): 243- 256.

5. Sallam N, Laher I. Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxid Med Cell Longev. 2016; 11: 216- 225

6. Friedenreich CM, O’Reilly R, Shaw E, Stanczyk FZ, Yasui Y, Brenner DR, et al. Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes. Cancer Prev. Res. 2016; 9: 196- 203

7. Ding YS, Guo SX, Ma RL, Li SG, Guo H, Zhang JY, and et al. Association of metabolic syndrome with the adiponectin to homeostasis model assessment of

insulin resistance ratio. Mediators Inflamm. 2015; 2015: 607364.

8. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2017; 114 (12): 1752- 1761.

9. Chen H, Fajol A, Hoene M, Zhang B, Schleicher ED, Lin Y, et al. PI3K- resistant GSK3 controls adiponectin formation and protects from metabolic syndrome. Proc Natl Acad Sci USA. 2016; 113 (20): 5754- 5759.

10. Ghadge AA, Khaire AA, Kuvalekar AA. Adiponectin: A potential therapeutic target for metabolic syndrome. Cytokine Growth Factor Rev. 2017; 1: 151- 158.

11. DeBoer MD, Gurka MJ, Morrison JA, Woo JG. Inter-relationships between the severity of metabolic syndrome, insulin and adiponectin and their relationship to future type 2 diabetes and cardiovascular disease. Int J Obes. 2016; 40 (9): 1353.

12. Pattyn N, Cornelissen VA, Eshghi SR, Vanhees L. The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome. Sports Med. 2013; 43 (2): 121- 133.

13. Naci H, Ioannidis JP. Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. BMJ. 2013; 347: f5577.

14. Bakker EA, Lee DC, Sui X, Artero EG, Ruiz JR, Eijsvogels TM, et al. Association of resistance exercise, independent of and combined with aerobic exercise, with the incidence of metabolic syndrome. Mayo Clin Proc. 2017; 92 (8): 1214- 1222.

15. Lemes ÍR, Ferreira PH, Linares SN, Machado AF, Pastre CM, Netto J. Resistance training reduces systolic blood pressure in metabolic syndrome: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med. 2016; 50: 1425- 1425.

16. Bateman LA, Slentz CA, Willis LH, Shields AT, Piner LW, Bales CW, et al. Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the studies of a targeted risk reduction intervention through defined exercise- STRRIDE- AT/RT). Am J Cardiol. 2011; 108 (6): 838- 844.

17. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005; 98 (4): 1154- 1162.

18. Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr. 2004; 79 (4): 544- 551.

19. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and Plasma C‐reactive protein and interleukin‐ 6 in elderly people. J Am Geriatr Soc. 2008; 56 (11): 2045- 2052.

20. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010; 411 (11- 12): 785- 793.

21. Bloomer RJ. The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Sports Med. 2007; 37 (6): 519- 532.

22. Jackson AS, Pollock ML, Gettman LR. Intertester reliability of selected skinfold and circumference measurements and percent fat estimates. Res Q. 1978; 49 (4): 546- 551.

23. Froelicher VF, Thompson AJ, Noguera I, Davis G, Stewart AJ, Triebwasser JH. Prediction of maximal oxygen consumption: comparison of the Bruce and Balke treadmill protocols. Chest. 1975; 68 (3): 331- 336.

24. Wolpern AE, Burgos DJ, Janot JM, Dalleck LC. Is a threshold-based model a superior method to the relative percent concept for establishing individual exercise intensity? a randomized controlled trial. BMC Sports Sci Med Rehabil. 2015; 7 (1): 16.

25. Libardi CA, De GS, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc. 2012; 44 (1): 50- 56.

26. Kaspar F, Jelinek HF, Perkins S, Al-Aubaidy HA, Dejong B, Butkowski E. Acute-phase inflammatory response to single-bout HIIT and endurance training: a comparative study. Mediators Inflamm. 2016; 2016: 5474837.

27. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatr. 2005; 115 (4): e500-3.

28. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011; 106 (S3): S1- 78.

29. Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, et al. 2016 european society of hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016; 34 (10): 1887- 1920.

30. Brochu M, Tchernof A, Dionne IJ, Sites CK, Eltabbakh GH, Sims EA, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?. Int J Clin Endocrinol Metab. 2001; 86 (3): 1020- 1025.

31. Wackerhage H. Molecular exercise physiology: an introduction. Routledge. 2014.

32. Oberbach A, Tönjes A, Klöting N, Fasshauer M, Kratzsch J, Busse MW, et al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocr. 2006; 154 (4): 577- 585.

33. Lakka TA, Lakka HM, Rankinen T, Leon AS, Rao DC, Skinner JS, et al. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. Eur Heart J. 2005; 26 (19): 2018- 2025.

34. Martins RA, Neves AP, Coelho-Silva MJ, Veríssimo MT, Teixeira AM. The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults. Eur J Appl Physiol. 2010; 110 (1): 161- 169.

35. Fisher G, Hyatt TC, Hunter GR, Oster RA, Desmond RA, Gower BA. Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women. Obesity. 2011; 19 (6): 1131- 1136.

36. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J. 2001; 22 (9): 791- 797.

37. Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, et al. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PloS one. 2011; 6 (1): e14525.

38. O'Neill HM. AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes Metab J. 2013; 37 (1): 1- 21.

39. Greenfield JR, Campbell LV. Insulin resistance and obesity. Clin Dermatol. 2004; 22 (4): 289- 295.

40. Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. Int J Clin Endocrinol Metab. 2000; 85 (7): 2463- 2468.

41. Lindegaard B, Hansen T, Hvid T, Van Hall G, Plomgaard P, Ditlevsen S, et al. The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy. Int J Clin Endocrinol Metab. 2008; 93 (10): 3860- 3869.

42. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. Eur J Endocrinol. 2007; 157 (5): 625- 631.

43. Smart NA, Larsen AI, Le Maitre JP, Ferraz AS. Effect of exercise training on interleukin-6, tumour necrosis factor alpha and functional capacity in heart failure. Cardiol Res Pract. 2011; 532620.

44. Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci. 2009; 27 (14): 1607- 1615.

45. Speaker KJ, Fleshner M. Interleukin-1 beta: a potential link between stress and the development of visceral obesity. BMC Physiol. 2012; 12 (1): 8- 12.

46. Von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, Rothenbacher D. Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. Clin Chem. 2006; 52 (5): 853- 859.