Effect of Training Intensity on Serum Leptin and Adiponectin in Male and Female Futsal Players

Document Type : Original Article

Authors

• Abdosaleh Zar ¹
• Hassanali Abedi ²
• Fatemeh Ahmadi ³
• Mohammad Amin Safari ⁴
• Safar Zarei ⁵
• Hamid Asadnejad ⁶
• Milad Sharifian ⁶

¹ Department of Sport Science, Jahrom University, Jahrom, Iran

² Research Center for Non- Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran

³ Department of Exercise Physiology, Shahid Chamran University, Ahvaz, Iran

⁴ Department of Exercise Physiology, Shiraz University, Shiraz, Iran

⁵ Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran

⁶ Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran

Abstract

Introduction: According to the effect of gender on leptin and adiponectin and the inconsistent effects of exercise intensity on these two hormones, the present study aims to evaluate the effect of different exercise intensities in the play-ground on serum levels of leptin and adiponectin of male and female futsal players. Methods: This clinical trial study is done on 12 male and 12 female futsal players. They started the moderate intensity exercise (65% of maximum heart rate) in the play-ground, followed by high intensity exercise (80% of maximum heart rate) next week. Before and after each exercise, blood sample was collected from the players to measure the serum levels of leptin and adiponectin. The data collected was analyzed by ANCOVA, using SPSS. Results: Leptin level was significantly higher in females before exercise (p=0.000). Neither moderate nor high intensity exercise had effect on serum levels of males (p=0.69) and females (p=0.261). Leptin levels of males and females were significantly different after moderate (p=0.003) and high intensity (p=0.023) exercise. Exercise intensity did not affect the levels of adiponectin in females (p=0.118) and males (p=0.435). Adiponectin levels of males and females were not different after moderate (p=0.179) and high intensity (p=0.173) exercise. Conclusion: Exercise intensity (moderate and high) doesn’t affect the serum levels of leptin and adiponectin in male and female futsal players. So, to levels of these hormones, it doesn’t matter how hard the player exercises.

Keywords

• Training
• Leptin
• Adiponectin
• Futsal

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References

1. Xin L, Huang WX, LU JM, Guang Y, Ling F, Lan YT, et al. Effects of a multivitamin/multimineral supplement on young males with physical overtraining: a placebo-controlled, randomized, double-blinded cross-over trial. Biomed Environ Sci. 2013; 26 (7): 599- 604.

2. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004; 50 (9): 1511- 1525.

3. do Carmo Martins M, Faleiro LL, Fonseca A. Relationship between leptin and body mass and metabolic syndrome in an adult population. RPC. 2012; 31 (11): 711- 719.

4. Avery P, Barzilai N, Benetos A, Bilianou H, Capri M, Caruso C, et al. Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement. Current Vas Pharm. 2014; 12 (5): 659- 661.

5. Radin MJ, Sharkey LC, Holycross BJ. Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses. Veter Clin Pathology. 2009; 38 (2): 136- 156.

6. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med. 2010; 44 (9): 620- 630.

7. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Sci J. 1995; 269 (5223): 543- 545.

8. Bouassida A, Lakhdar N, Benaissa N, Mejri S, Zaouali M, Zbidi A, et al. Adiponectin responses to acute moderate and heavy exercises in overweight middle aged subjects. J Sports Med Phy Fitness. 2010; 50 (3): 330- 335.

9. Berezina A, Belyaeva O, Berkovich O, Baranova E, Karonova T, Bazhenova E, et al. Prevalence, risk factors, and genetic traits in metabolically healthy and unhealthy obese individuals. BioMed Res Int. 2015; 2015.

10. Sahin- efe A, Upadhyay J, Ko B-J, Dincer F, Park KH, Migdal A, et al. Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: a cross sectional and a prospective case-control study nested in the normative aging study. Metab J. 2018; 79: 24- 32.

11. Hee Park K, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrin Metab. 2013; 98 (12): 4899- 4907.

12. Blüher S, Mantzoros CS. The role of leptin in regulating neuroendocrine function in humans. J Nutr. 2004; 134 (9): 2469S- 2474S.

13. Baltzegar DA, Reading BJ, Douros JD, Borski RJ. Role for leptin in promoting glucose mobilization during acute hyperosmotic stress in teleost fishes. J Endocrin. 2014; 220 (1): 61- 72.

14. Taher Z, Hamedinia M. Investigation of effect of one session moderate and heavy resistance exercise on acute and delayed responses of leptin, insulin, cortisol, testosterone and 24 hour energy expenditure in healthy men. Iranian J Endocrin Metab. 2011; 13 (1): 67- 73.

15. Racil G, Coquart JB, Elmontassar W, Haddad M, Goebel R, Chaouachi A, et al. Greater effects of high-compared with moderate-intensity interval training on cardio-metabolic variables, blood leptin concentration and ratings of perceived exertion in obese adolescent females. Biol Sport. 2016; 33 (2): 145.

16. Sturgeon K, Digiovanni L, Good J, Salvatore D, Fenderson D, Domchek S, et al. Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer. Cancer Epidemiology and Prevention Biomarkers. 2016; 25 (8): 1195- 1200.

17. Voss S, Nikolovski Z, Bourdon P, Alsayrafi M, Schumacher Y. The effect of cumulative endurance exercise on leptin and adiponectin and their role as markers to monitor training load. Biol Sport. 2016; 33 (1): 23.

18. Laursen TL, Zak RB, Shute RJ, Heesch MW, Dinan NE, Bubak MP, et al. Leptin, adiponectin, and ghrelin responses to endurance exercise in different ambient conditions. Temperature. 2017: 1- 10.

19. Poonpet T, Honsawek S. Adipokines: Biomarkers for osteoarthritis? World J Orth. 2014; 5 (3): 319.

20. Letra L, Santana I, Seiça R. Obesity as a risk factor for Alzheimer’s disease: the role of adipocytokines. Metab Brain Dis. 2014; 29 (3): 563- 568.

21. Ricci R, Bevilacqua F. The potential role of leptin and adiponectin in obesity: a comparative review. Veterinary J. 2012; 191 (3): 292- 298.

22. Pan H, Guo J, Su Z. Advances in understanding the interrelations between leptin resistance and obesity. Physiol Beh. 2014; 130: 157- 169.

23. Husseini M, Nikbakht M, Habibi A, Ahangarpour A. Acute effects of anaerobic exhastive encermental exercise session on serum leption and plasma lipids. Jundishapour Sci Med Univ J. 2011; 10 (4): 363- 371.

24. Hada Y, Yamauchi T, Waki H, Tsuchida A, Hara K, Yago H, et al. Selective purification and characterization of adiponectin multimer species from human plasma. Biochem Biophys Res Communications. 2007; 356 (2): 487- 493.

25. Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, et al. Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor α in obese women. Metab J. 2006; 55 (10): 1375- 1381.

26. Lakhdar N, Saad HB, Denguezli M, Zaouali M, Zbidi A, Tabka Z, et al. Effects of intense cycling training on plasma leptin and adiponectin and its relation to insulin resistance. Neuroendocrinology Letters. 2013; 34 (3): 229- 235.

27. Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003; 52 (2): 268- 276.

28. Atashak S, Jafari A, Azarbayjani MA. The influences of long-term resistance training on Adiponectin and lipid profiles levels in obese men. Razi Med Sci J. 2011; 18 (86): 1- 11.

29. Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrin Metab. 1997; 82 (4): 1293- 1300.

30. Hickey MS, Houmard JA, Considine RV, Tyndall GL, Midgette JB, Gavigan KE, et al. Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Phys Endocrin Metab. 1997; 272 (4): E562- E566.

31. Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H. Perceived psychological stress and serum leptin concentrations in Japanese men. Obesity J. 2006; 14 (10): 1832- 1838.

32. Swarbrick MM, Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndrome Related Dis. 2008; 6 (2): 87- 102.

33. Laughlin GA, Barrett‐Connor E, May S. Sex–specific association of the androgen to oestrogen ratio with adipocytokine levels in older adults: the Rancho Bernardo Study. Clin Endocrin. 2006; 65 (4): 506- 513.

34. Cnop M, Havel P, Utzschneider K, Carr D, Sinha M, Boyko E, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003; 46 (4): 459- 469.

35. Zar A, Ahmadi F, Miri M, Abedi HA, Salesi M. Cytokine pattern is affected by training intensity in women futsal players. Immune Network. 2016; 16 (2): 109- 115.

36. Poehlman ET. A review: exercise and its influence on resting energy metabolism in man. Med Sci Sports Ex. 1989; 21 (5): 515- 525.

37. Roupas ND, Mamali I, Maragkos S, Leonidou L, Armeni AK, Markantes GK, et al. The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race. Hormones (Athens). 2013; 12 (2): 275- 282.

38. Bouassida A, Zalleg D, Bouassida S, Zaouali M, Feki Y, Zbidi A, et al. Leptin, its implication in physical exercise and training: a short review. J Sports Sci Med. 2006; 5 (2): 172.

39. Unal M, Unal DO, Salman F, Baltaci AK, Mogulkoc R. The relation between serum leptin levels and VO2max in male patients with type I diabetes and healthy sedentary males. Endocrin Res. 2004; 30 (3): 491- 498.

40. Kristensen K, Pedersen SB, Richelsen B. Regulation of leptin by steroid hormones in rat adipose tissue. Biochem Biophysical Res Communications. 1999; 259 (3): 624- 630.

41. Paolisso G, Rizzo MR, Mone CM, Tagliamonte MR, Gambardella A, Riondino M, et al. Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrin. 1998; 48 (3): 291- 297.

42. Hosseini M, Nikbakht M, Habibi A, Ahangarpour A. Acute effects of an aerobic exhaustive incremental exercise session on serum leptin and plasma lipids. Ahwaz Med Sci Univ J. 2011; 10 (37):

363- 371.

43. Hamedinia M, Haghighi A. Investigation of effect of one session moderate and heavy resistance exercise on acute and delayed responses of leptin, insulin, cortisol, testosterone and 24- hour energy expenditure in healthy men. Iranian J Endocrin Metab. 2011; 13 (1): 67- 73.

44. Azarbayejani M, Abedi B, Piri M, Rasaie M. The Effects of a single session of combined aerobic and resistance exercise on leptin levels and insulin resistance index in sedentary men. Qom Univ Med Sci J. 2012; 6 (1): 46- 54.

45. Benatti FB, Lancha Junior AH. Leptin and endurance exercise: implications of adiposity and insulin. Revista Brasileira de Med Esporte. 2007; 13 (4): 263- 269.

46. Yu N, Ruan Y, Gao X, Sun J. Systematic review and meta-analysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals. Hormone Metab Res. 2017; 49 (3): 164- 173.

47. Bouassida A, Zalleg D, Bouassida S, Zaouali M, Feki Y, Zbidi A, et al. Leptin, its implication in physical exercise and training: a short review. J Sports Sci Med. 2006; 5 (2): 172- 181.

48. Jürimäe J, Hofmann P, Jürimäe T, Mäestu J, Purge P, Wonisch M, et al. Plasma adiponectin response to sculling exercise at individual anaerobic threshold in college level male rowers. Int J Sports Med. 2006; 27 (4): 272- 277.