The Effect of High Intensity Interval Training on the Response of Coagulation and Fibrinolytic Factors of Hypertensive Patients to One Bout Submaximal Endurance Exercise

Document Type : Original Article


1 Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Exercise Sciences, Human Performance Laboratory, Ball State University, Muncie, Indiana, America


Introduction: Extensive evidence has shown that high intensity exercise triggers blood coagulation and improves blood fibrinolysis levels. The purpose of the present study was to investigate the effect of 12 weeks of high intensity interval training (HIIT) on the response of coagulation, anticoagulant and fibrinolytic factors of hypertensive cardiovascular patients to one bout submaximal endurance exercise (OBSEE). Methods: Out of 70 men with high blood pressure, 20 men were selected based on inclusion and exclusion criteria and randomly divided into two equal groups: an experimental group (EG) and a control group (CG). First, both groups performed OBSEE. After that, the EG performed 12 weeks of HIIT. At the end, again, both groups performed OBSEE. Blood sampling was performed just before and immediately after each session of exercise. Dependent variables were categorized into three groups including 1. Coagulation: fibrinogen(FIB), factor VIII(FVIII), prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (aPTT), platelet (PLT), mean platelet volume (MPV) 2. Anticoagulation: protein C (PC), antithrombinIII (ATIII) 3. Fibrinolytic: d-dimer (D-D), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI-I), tPA/PAI-1. To analyze the data, Shapiro- Wilk test, Factorial repeated measures ANOVA, as well as Pearson correlation coefficient were used at significant level (P ≤ 0.05). Results: HIIT caused significant increase in the rate of Vo2max (p = 0.001) and significant decrease in RHR (p = 0.001), SBP (p = 0.001) and DBP (p = 0.001). No significant difference was observed between the two groups in the response of FIB (p = 0.262), FVIII (p = 0.248), PT (p = 0.396), PTA (p = 0.646), INR (p = 0.408), aPTT (p = 0.856), PLT (p = 0.678), MPV (p = 0.223), D-D (p = 0.621), tPA (p = 0.381), PAI-1 (p = 0.353), tPA / PAI-1 (p = 0.069), PC (p = 0.147) and ATIII (p = 0.138) to OBSEE after 12 weeks HIIT. Conclusion: It seems that to observation of significant positive changes in the response of coagulation, anticoagulant, and fibrinolytic factors to one OBSEE, more than 12 weeks HIIT are required.


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